Polymeric nanogels as vaccine delivery systems

Polymeric nanogels as vaccine delivery systems.

UNLABELLED Polymeric nanogels find a relevant field of application in the formulation of a new generation of therapeutic and preventive vaccines, aiming at the fine-tuned modulation of the immune response. Intrinsic properties of polymeric nanogels, such as material chemistry, size and shape, surface charge, and hydrophobicity or hydrophilicity, may be determining factors in shaping the induced...

Polymeric Nanogels as Gene Carriers

Polymeric nanogels produced via inverse microemulsion polymerization as potential gene and antisense delivery agents.

Polymeric nanogel vectors were developed for cellular gene and antisense delivery. Inverse microemulsion polymerization was utilized to synthesize biocompatible nanogels with controlled size, morphology, and composition. The chemical composition, size, polydispersity, stability, and swelling behavior of the nanogels were investigated by NMR, light scattering, transmission electron microscopy, a...

Biodegradable particles as vaccine delivery systems

ii AKNOWLEDGEMENTS I would like to extend heartfelt gratitude to my teachers, colleagues and friends for their support and help that has brought this thesis research to a successful completion. I am deeply indebted to my supervisor Dr. Aliasger Salem for giving me the grand opportunity to undertake this thesis research. His awe-inspiring personality, stimulating suggestions and encouragement ha...

Chitosan Microspheres as Potential Vaccine Delivery Systems

The recent advances in controlled delivery systems for protein pharmaceuticals such as microspheres, liposomes, pumps and implants, have provided a new avenue for delivery of vaccine antigens. Adjuvants aimed at increasing the immunogenicity of recombinant antigens remain a focus in vaccine development worldwide, there is currently considerable care for the development of chitosan microspheres ...